MIT OpenCourseWare: New Courses in Biology

7.346 Cellular Garbage Disposal: Misfolded Proteins in Normal Biology and Human Disease (MIT)

Sanyal, Sumana — 2011-12-15T16:53:53+05:00

The endoplasmic reticulum (ER) orchestrates different cellular processes by which proteins are synthesized, correctly folded, modified and ultimately transported to their final destinations. As part of this crucial biosynthetic process, proteins that are not properly folded and consequently detrimental to normal cellular function are constantly generated. A common signature of many neurodegenerative diseases, including Alzheimer's and Parkinson's, is accumulation and deposition of misfolded proteins that arise when the ability of cells to deal with the burden of misfolded proteins is compromised. In this course, we will explore how the ER quality control machinery ensures that only properly assembled proteins exit the ER while distinguishing between nascent proteins en route to their biologically active folded state from those that are terminally misfolded.

7.342 The Biology of Aging: Age-Related Diseases and Interventions (MIT)

Lamming, Dudley W. — 2011-12-13T16:31:46+05:00

Aging involves an intrinsic and progressive decline in function that eventually will affect us all. While everyone is familiar with aging, many basic questions about aging are mysterious. Why are older people more likely to experience diseases like cancer, stroke, and neurodegenerative disorders? What changes happen at the molecular and cellular levels to cause the changes that we associate with old age? Is aging itself a disease, and can we successfully intervene in the aging process?This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

7.347 Fueling Sustainability: Engineering Microbial Systems for Biofuel Production (MIT)

O'Malley, Michelle — 2011-09-06T17:22:27+05:00

The need to identify sustainable forms of energy as an alternative to our dependence on depleting worldwide oil reserves is one of the grand challenges of our time. The energy from the sun converted into plant biomass is the most promising renewable resource available to humanity. This seminar will examine each of the critical steps along the pathway towards the conversion of plant biomass into ethanol. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.